HRID455916

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCc1nn(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)[nH]c12.Cl

HCID178440328

未命名化合物

HCID178512922

未命名化合物

PRODUCTS

生成物

结构：CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12.N=C(N)NCCC[C@H](N)C(=O)O

HCID178440329

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

2 次

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

In a flask equipped with a magnetic stirrer, Sildenafil HCl (8.8 g) is dissolved in a mixture of ethanol (100 mL) and water (30 mL), added an ethanol solution of Arginine sodium then reacted at 50° C. for 60 mins. After cooling, a white precipitate is obtained and the sodium chloride is removed by filtration. The methanol is added under room temperature and being incubated over night for re-precipitation. The Sildenafil-L-Arginine complex salt (10.8 g) is obtained after filtering the crystal.

WORKUP

后处理

customIn a flask equipped with a magnetic stirrer
customthen reacted at 50° C. for 60 mins
temperatureAfter cooling
customa white precipitate is obtained
customthe sodium chloride is removed by filtration
additionThe methanol is added under room temperature
custombeing incubated over night for re-precipitation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-da34c96db28d45779d7503fb7db7c074
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08497370B2
来源说明: uspto-grants-2013_07

反应 SMILES

[CH3:1][CH2:2][CH2:3][C:4]1[C:8]2[NH:9][C:10]([C:14]3[CH:19]=[C:18]([S:20]([N:23]4[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]4)(=[O:22])=[O:21])[CH:17]=[CH:16][C:15]=3[O:30][CH2:31][CH3:32])=[N:11][C:12](=[O:13])[C:7]=2[N:6]([CH3:33])[N:5]=1.Cl.[Na].[NH2:36][C@H:37]([C:45]([OH:47])=[O:46])[CH2:38][CH2:39][CH2:40][NH:41][C:42](=[NH:44])[NH2:43]>C(O)C.O>[CH3:1][CH2:2][CH2:3][C:4]1[C:8]2[N:9]=[C:10]([C:14]3[CH:19]=[C:18]([S:20]([N:23]4[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]4)(=[O:21])=[O:22])[CH:17]=[CH:16][C:15]=3[O:30][CH2:31][CH3:32])[NH:11][C:12](=[O:13])[C:7]=2[N:6]([CH3:33])[N:5]=1.[NH2:36][C@H:37]([C:45]([OH:47])=[O:46])[CH2:38][CH2:39][CH2:40][NH:41][C:42](=[NH:43])[NH2:44]