HCID 178440328, compound → HCID 178440329, compound

Participants

Reaction Steps

In a flask equipped with a magnetic stirrer, Sildenafil HCl (8.8 g) is dissolved in a mixture of ethanol (100 mL) and water (30 mL), added an ethanol solution of Arginine sodium then reacted at 50° C. for 60 mins. After cooling, a white precipitate is obtained and the sodium chloride is removed by filtration. The methanol is added under room temperature and being incubated over night for re-precipitation. The Sildenafil-L-Arginine complex salt (10.8 g) is obtained after filtering the crystal.

Provenance & Evidence