反应详情

To a solution of 4-chloro-6,7-dimethoxyquinazoline (1 equiv.) in 2 ml CH3CN were added 6-hydroxy-N,2-dimethylbenzofuran-3-carboxamide (1 equiv.) and K2CO3 (1.5 equiv.). The mixture was refluxed under stirring for 10 hr. After the solvent was evaporated, the residue was washed with water, dried over MgSO4, filtered, concentrated, and purified by column chromatography to give the title compound in a yield of 85%.

1. temperatureThe mixture was refluxed
2. customAfter the solvent was evaporated
3. washthe residue was washed with water
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated
7. custompurified by column chromatography