反应详情

5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid (1.6 g, 6.0 mmol), diphenylphosphoryl azide (1.6 g, 6.0 mmol), and triethylamine (1.3 mL, 9.3 mmol) were combined in t-BuOH and refluxed overnight. After cooling, the mixture was concentrated, and the residue was partitioned between EtOAc and H2O. The organic layer was separated and concentrated, and the residue was purified by silica gel chromatography (16-18% EtOAc in hexanes) to give the title compound.

1. temperaturerefluxed overnight
2. temperatureAfter cooling
3. concentrationthe mixture was concentrated
4. customthe residue was partitioned between EtOAc and H2O
5. customThe organic layer was separated
6. concentrationconcentrated
7. customthe residue was purified by silica gel chromatography (16-18% EtOAc in hexanes)