反应详情

The known method for the manufacture of ferroquine, partially represented in scheme 2 below, consists in synthesizing firstly 1-[(dimethylamino)methyl]-2-formyl-ferrocene from (dimethylamino)methyl-ferrocene with a yield of about 85%, then in preparing the corresponding intermediate oxime, and finally in carrying out reduction of this oxime which leads to obtaining 1-(aminomethyl)-2-[(dimethylamino)methyl]-ferrocene which can be isolated in the form of dihydrochloride. The yield of synthesis of the dihydrochloride 1-(aminomethyl)-2-[(dimethylamino)methyl]-ferrocene relative to 1-[(dimethylamino)methyl]-2-formyl-ferrocene is 55-65%.