HuagongsheHuagongshe Chemistry Print Report · For research reference only
cyclopenta-1,3-diene;1-cyclopenta-2,4-dien-1-yl-N,N-dimethylmethanamine;iron(2+) → HCID 178483164, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | cyclopenta-1,3-diene;1-cyclopenta-2,4-dien-1-yl-N,N-dimethylmethanamine;iron(2+) | HCID 15764045 | — |
| Reactant | 3-(((7-chloroquinolin-4-yl)amino)methyl)-4-((dimethylamino)methyl)cyclopenta-1,3-dien-1-ide cyclopenta-1,3-dien-1-ide iron(II) | HCID 56841801 | — |
| Reactant | HCID 178483165 | HCID 178483165 | — |
| Product | HCID 178483164 | HCID 178483164 | 85% |
Reaction Steps
The known method for the manufacture of ferroquine, partially represented in scheme 2 below, consists in synthesizing firstly 1-[(dimethylamino)methyl]-2-formyl-ferrocene from (dimethylamino)methyl-ferrocene with a yield of about 85%, then in preparing the corresponding intermediate oxime, and finally in carrying out reduction of this oxime which leads to obtaining 1-(aminomethyl)-2-[(dimethylamino)methyl]-ferrocene which can be isolated in the form of dihydrochloride. The yield of synthesis of the dihydrochloride 1-(aminomethyl)-2-[(dimethylamino)methyl]-ferrocene relative to 1-[(dimethylamino)methyl]-2-formyl-ferrocene is 55-65%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497375B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-4b5e27ef9e934a179090949985f2042d |
| Source note | uspto-grants-2013_07 |