反应详情

温度

60 °C

To a mixture of 3-t-butyl-5-[4-(3-t-butoxy carbonylamino-5-isoxazolyl)-phenyl]-4-(2-methoxyphenyl)-4,5-dihydro-1H-pyrrolo[3,4-c]pyrazol-6-one (0.036 g, 0.7 mmol) and methanol (2 mL), conc. hydrochloric acid (0.07 mL) was added, and the mixture was stirred at 60° C. for 2 hr. The precipitate was collected by filtration and recrystallized (methanol/dichloromethane) to give 3-t-butyl-5-[4-(3-amino-5-isoxazolyl)phenyl]-4-(2-methoxyphenyl)-4,5-dihydro-1H-pyrrolo[3,4-c]pyrazol-6-one (0.02 g, 68%) as pale yellow crystals.

1. additionwas added
2. filtrationThe precipitate was collected by filtration
3. customrecrystallized (methanol/dichloromethane)