Sodium Hydroxide → HCID 178424630, compound

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Reaction Steps

To a suspension of 4-cyano-1H-imidazole-2-carboxylic acid[2-(4,4-dimethyl-cyclohex-1-enyl)-6-(2,2,6,6-tetramethyl-tetrahydro-pyran-4-yl)-pyridin-3-yl]-amide (23.1 mg, 0.0500 mmol), as prepared in Example 15, in ethanol (1.0 mL) was added a solution of sodium hydroxide (1.0N; 0.055 mL; 0.055 mmol). The solution was allowed to evaporate in an open vial at room temperature. A white crystalline solid resulted and was characterized by PXRD and TGA (6.1% loss of mass). The PXRD of Form A of the sodium salt is shown in FIG. 2 and the prominent peaks provided in the table below.

Provenance & Evidence