Sodium Hydroxide → HCID 178424630, compound

HRID 456018Notes

Reaction equation

HRID 456018 reaction equation
[CH3:1][C:2]1([CH3:34])[CH2:7][CH2:6][C:5]([C:8]2[C:13]([NH:14][C:15]([C:17]3[NH:18][CH:19]=[C:20]([C:22]#[N:23])[N:21]=3)=[O:16])=[CH:12][CH:11]=[C:10]([CH:24]3[CH2:29][C:28]([CH3:31])([CH3:30])[O:27][C:26]([CH3:33])([CH3:32])[CH2:25]3)[N:9]=2)=[CH:4][CH2:3]1.[OH-].[Na+].[Na:37]>C(O)C>[Na:37].[CH3:1][C:2]1([CH3:34])[CH2:7][CH2:6][C:5]([C:8]2[C:13]([NH:14][C:15]([C:17]3[NH:18][CH:19]=[C:20]([C:22]#[N:23])[N:21]=3)=[O:16])=[CH:12][CH:11]=[C:10]([CH:24]3[CH2:25][C:26]([CH3:33])([CH3:32])[O:27][C:28]([CH3:31])([CH3:30])[CH2:29]3)[N:9]=2)=[CH:4][CH2:3]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 5360545SodiumHCID 178424627HCID 178424627, compound

Product 1

HCID 178424630HCID 178424630, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 4-cyano-1H-imidazole-2-carboxylic acid[2-(4,4-dimethyl-cyclohex-1-enyl)-6-(2,2,6,6-tetramethyl-tetrahydro-pyran-4-yl)-pyridin-3-yl]-amide (23.1 mg, 0.0500 mmol), as prepared in Example 15, in ethanol (1.0 mL) was added a solution of sodium hydroxide (1.0N; 0.055 mL; 0.055 mmol). The solution was allowed to evaporate in an open vial at room temperature. A white crystalline solid resulted and was characterized by PXRD and TGA (6.1% loss of mass). The PXRD of Form A of the sodium salt is shown in FIG. 2 and the prominent peaks provided in the table below.

Workup

  1. customto evaporate in an open vial at room temperature
  2. customA white crystalline solid resulted
  3. customthe prominent peaks provided in the table below

Sources & evidence

ORD record
ord-c65d860f566d4882bf3fa16699e17dd7
Source dataset
uspto-grants-2013_07
Patent number
US08497376B2

Reaction notes

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