Ethylhydrazine → HCID 50915828, compound

HRID 456065Notes

Reaction equation

HRID 456065 reaction equation
[CH2:1]([NH:3][NH2:4])[CH3:2].[F:5][C:6]1[CH:15]=[C:14]2[C:9]([CH:10]=[CH:11][CH:12]=[N:13]2)=[CH:8][C:7]=1[CH2:16][C:17]1[N:21]2[N:22]=[C:23]([C:26](=O)[CH3:27])[CH:24]=[CH:25][C:20]2=[N:19][CH:18]=1>>[CH2:1]([NH:3]/[N:4]=[C:26](/[C:23]1[CH:24]=[CH:25][C:20]2[N:21]([C:17]([CH2:16][C:7]3[CH:8]=[C:9]4[C:14](=[CH:15][C:6]=3[F:5])[N:13]=[CH:12][CH:11]=[CH:10]4)=[CH:18][N:19]=2)[N:22]=1)\[CH3:27])[CH3:2]

Participants

3

Reactant 2

HCID 29062EthylhydrazineHCID 581905991-[3-(7-Fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]ethanone

Product 1

HCID 50915828HCID 50915828, compoundYield 32%

Procedure

The title compound was prepared from ethyl hydrazine and 1-[3-(7-fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-ethanone in analogy to the synthesis of example 1 in 32% yield. 1H-NMR (400 MHz, MeOH -d4) δ ppm 8.81 (dd, 1H), 8.27 (d, 1H), 7.92 (d, 1H), 7.88 (d, 1H), 7.78 (d, 1H), 7.69 (d, 1H), 7.54 (s, 1H), 7.47 (q, 1H), 4.59 (s, 2H), 3.38 (q, 2H), 2.13 (s, 3H), 1.22 (t, 3H). LCMS (method A): [MH]+=363, tR=5.32 min.

Sources & evidence

ORD record
ord-8b78b18506ff4fbfabb1ae13dcf1361f
Source dataset
uspto-grants-2013_07
Patent number
US08497368B2

Reaction notes

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