Acetohydrazide → HCID 50915989, compound

HRID 456066Notes

Reaction equation

HRID 456066 reaction equation
[C:1]([NH:4][NH2:5])(=[O:3])[CH3:2].[F:6][C:7]1[CH:16]=[C:15]2[C:10]([CH:11]=[CH:12][CH:13]=[N:14]2)=[CH:9][C:8]=1[CH2:17][C:18]1[N:22]2[N:23]=[C:24]([C:27](=O)[CH3:28])[CH:25]=[CH:26][C:21]2=[N:20][CH:19]=1>>[F:6][C:7]1[CH:16]=[C:15]2[C:10]([CH:11]=[CH:12][CH:13]=[N:14]2)=[CH:9][C:8]=1[CH2:17][C:18]1[N:22]2[N:23]=[C:24](/[C:27](=[N:5]/[NH:4][C:1](=[O:3])[CH3:2])/[CH3:28])[CH:25]=[CH:26][C:21]2=[N:20][CH:19]=1

Participants

3

Reactant 2

HCID 14039AcetohydrazideHCID 581905991-[3-(7-Fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]ethanone

Product 1

HCID 50915989HCID 50915989, compoundYield 75%

Procedure

The title compound was prepared from acetic hydrazide and 1-[3-(7-fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-ethanone in analogy to the synthesis of example 1 in 75% yield as a white solid. 1H-NMR (400 MHz, DMSO-d6) δ ppm 8.86 (d, 1H), 8.83 (d, 1H), 8.07 (d, 1H), 7.95 (d, 1H), 7.79 (m, 2H), 7.70 (s, 1H), 7.47 (q, 1H), 4.58 (s, 2H), 2.28 (s, 3H). LCMS (method A): [MH]+=377, tR=4.83 min.

Sources & evidence

ORD record
ord-04b873f6cf944e2fb56f88d0173c843d
Source dataset
uspto-grants-2013_07
Patent number
US08497368B2

Reaction notes

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