Morpholine → 2-Fluoro-4-morpholinobenzonitrile

HRID 45608ノート

反応式

HRID 45608 の反応式
[F:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>O1CCCC1>[F:1][C:2]1[CH:9]=[C:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

参加物

4

反応物 2

HCID 8083MorpholineHCID 775452,4-Difluorobenzonitrile

生成物 1

HCID 210699252-Fluoro-4-morpholinobenzonitrile収率 65%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 2,4-difluorobenzonitrile (6.03 g, 43.35 mmol) and morpholine (8.3 ml, 95.17 mmol) in tetrahydrofuran (27 ml) was stirred at room temperature for 24 hr. The mixture was evaporated and the white solid purified by Biotage™ column (90 g, silica) eluting with cyclohexane:ethyl acetate: (4:1) to give 2-fluoro-4-(morpholino)-benzonitrile as a white solid (5.81 g, 65%).

後処理

  1. customThe mixture was evaporated
  2. customthe white solid purified by Biotage™ column (90 g, silica)
  3. washeluting with cyclohexane

出典と根拠

ORDレコード
ord-fe7c453dc1e84ed48bb0650f1f54c9d5
出典データセット
uspto-grants-2013_09
特許番号
US08541579B2

反応ノート

読み込み中…