反应详情

To a solution of (6-chloroimidazo[1,2-b]pyridazin-3-yl)(7-fluoroquinolin-6-yl)methanone (2.93 g, 6.73 mmol) in THF (80 mL) was added MeMgl solution (4.48 mL, 13.45 mmol). The resulting solution was allowed to stir at reflux for 5 hrs. Then the reaction mixture was cooled to room temperature, quenched with water, washed with NH4Cl solution and extracted by CH2Cl2. The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure to afford 2.2 g (yield: 95%) title compound which was used to next step without further purification. LCMS (method B): [MH]+=343, tR=2.05 min.

1. temperatureat reflux for 5 hrs
2. customquenched with water
3. washwashed with NH4Cl solution
4. extractionextracted by CH2Cl2
5. dry with materialThe combined organic layers were dried over Na2SO4
6. concentrationconcentrated under reduced pressure