反应详情

温度

140 °C

A microwave tube was charged with 1-quinolin-6-yl-cyclopropanecarboxylic acid hydrazide (513 mg, 2.26 mmol), 3,6-dichloropyridazine (437 mg, 2.93 mmol) and n-butanol (5 mL). The mixture was heated at 140° C. for 12 h. The solvent was removed in vacuo and the residue was purified by flash chromatography in silica gel eluting with ETOAC/methanol gradient to afford 196 mg (41%) of the title compound. LCMS (method A): [MH]+=322, tR=4.38 min.

1. customThe solvent was removed in vacuo
2. customthe residue was purified by flash chromatography in silica gel eluting with ETOAC/methanol gradient