3,6-Dichloropyridazine → 6-(1-(6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)cyclopropyl)quinoline

Participants

Reaction Conditions

Reaction Steps

A microwave tube was charged with 1-quinolin-6-yl-cyclopropanecarboxylic acid hydrazide (513 mg, 2.26 mmol), 3,6-dichloropyridazine (437 mg, 2.93 mmol) and n-butanol (5 mL). The mixture was heated at 140° C. for 12 h. The solvent was removed in vacuo and the residue was purified by flash chromatography in silica gel eluting with ETOAC/methanol gradient to afford 196 mg (41%) of the title compound. LCMS (method A): [MH]+=322, tR=4.38 min.

Provenance & Evidence