Semicarbazide hydrochloride → HCID 50915826, compound
Reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([CH2:11][N:12]3[C:16]4=[N:17][C:18]([C:21](=[N:23][NH2:24])[NH2:22])=[CH:19][N:20]=[C:15]4[N:14]=[N:13]3)=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.N1C2C(=CC(CN3C4=NC(C#N)=CN=C4N=N3)=CC=2)C=CC=1.Cl.[NH:48]([C:50](N)=[O:51])N>>[NH2:22]/[C:21](/[C:18]1[N:17]=[C:16]2[N:12]([CH2:11][C:7]3[CH:6]=[C:5]4[C:10](=[CH:9][CH:8]=3)[N:1]=[CH:2][CH:3]=[CH:4]4)[N:13]=[N:14][C:15]2=[N:20][CH:19]=1)=[N:23]/[NH:24][C:50]([NH2:48])=[O:51]Participants
4
Procedure
The title compound was prepared in analogy to the synthesis of compound 64.2 from 1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-6-carbonitrile and hydrazinecarbox-amide hydrochloride. 1H-NMR (400 MHz, DMSO-d6) δ ppm 9.80 (s, 1H), 8.88 (m, 1H), 8.34 (d, 1H), 8.05 (d, 1H), 8.00 (d, 1H), 7.86 (d, 1H), 7.52 (dd, 1H), 6.18 (s, 2H). LCMS (method B): [MH]+=363, tR=1.70 min.
Sources & evidence
- ORD record
- ord-18922038128c41c5a9e63dbb0b9fb41b
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08497368B2
Reaction notes
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