6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine → 6-Bromo-N2-(1-(7-fluoroquinolin-6-yl)ethyl)pyrazine-2,3-diamine

HRID 456141Notes

Reaction equation

HRID 456141 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[CH:12]([NH2:14])[CH3:13].[Br:15][C:16]1[N:21]=[C:20](NCC2C=C3C(=CC=2)N=CC=C3)[C:19]([NH2:34])=[N:18][CH:17]=1>>[Br:15][C:16]1[N:21]=[C:20]([NH:14][CH:12]([C:3]2[CH:4]=[C:5]3[C:10](=[CH:11][C:2]=2[F:1])[N:9]=[CH:8][CH:7]=[CH:6]3)[CH3:13])[C:19]([NH2:34])=[N:18][CH:17]=1

Participants

3

Reactant 2

HCID 457894186-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamineHCID 669270791-(7-Fluoroquinolin-6-yl)ethanamine

Product 1

HCID 866660816-Bromo-N2-(1-(7-fluoroquinolin-6-yl)ethyl)pyrazine-2,3-diamine

Procedure

The title compound was prepared as a white solid from 1-(7-fluoroquinolin-6-yl)ethanamine in analogy to the synthesis of compound 52.1. LCMS (method B): [MH]+=364, tR=2.38 min.

Sources & evidence

ORD record
ord-763d0e03ef1541a68ee84878f084c937
Source dataset
uspto-grants-2013_07
Patent number
US08497368B2

Reaction notes

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