6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinoline → 6-(1-(6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline

HRID 456142Notes

Reaction equation

HRID 456142 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([NH:8][CH:9]([C:11]2[CH:12]=[C:13]3[C:18](=[CH:19][C:20]=2[F:21])[N:17]=[CH:16][CH:15]=[CH:14]3)[CH3:10])[C:5]([NH2:22])=[N:4][CH:3]=1.BrC1N=C2N(CC3C=C4C(=CC=3)N=CC=C4)N=NC2=[N:26]C=1>>[Br:1][C:2]1[N:7]=[C:6]2[N:8]([CH:9]([C:11]3[CH:12]=[C:13]4[C:18](=[CH:19][C:20]=3[F:21])[N:17]=[CH:16][CH:15]=[CH:14]4)[CH3:10])[N:26]=[N:22][C:5]2=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 547756086-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinolineHCID 866660816-Bromo-N2-(1-(7-fluoroquinolin-6-yl)ethyl)pyrazine-2,3-diamine

Product 1

HCID 866660826-(1-(6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline

Procedure

The title compound was prepared from 6-bromo-N2-(1-(7-fluoroquinolin-6-yl)ethyl)pyrazine-2,3-diamine in analogy to the synthesis of compound 52.2. LCMS (method B): [MH]+=345, tR=2.36 min.

Sources & evidence

ORD record
ord-dd54bfc42aa348ca857c9b6ff77d24a6
Source dataset
uspto-grants-2013_07
Patent number
US08497368B2

Reaction notes

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