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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 456142Generated: October 29, 2026

6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinoline → 6-(1-(6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline

https://huagongshe.com/reaction/456142

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinolineHCID 54775608—
Reactant6-Bromo-N2-(1-(7-fluoroquinolin-6-yl)ethyl)pyrazine-2,3-diamineHCID 86666081—
Product6-(1-(6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinolineHCID 86666082—

Reaction Steps

The title compound was prepared from 6-bromo-N2-(1-(7-fluoroquinolin-6-yl)ethyl)pyrazine-2,3-diamine in analogy to the synthesis of compound 52.2. LCMS (method B): [MH]+=345, tR=2.36 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08497368B2
Source datasetuspto-grants-2013_07
ORD IDord-dd54bfc42aa348ca857c9b6ff77d24a6
Source noteuspto-grants-2013_07