Hydrochloric Acid → 1-(3-(1-(1-Methyl-1H-indazol-5-yl)ethyl)imidazo[1,2-b]pyridazin-6-yl)ethanone

HRID 456162Notes

Reaction equation

HRID 456162 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]2[N:10]([C:12]([CH:15]([C:17]3[CH:18]=[C:19]4[C:23](=[CH:24][CH:25]=3)[N:22]([CH3:26])[N:21]=[CH:20]4)[CH3:16])=[CH:13][N:14]=2)[N:11]=1)=[CH2:5])C.Cl>>[CH3:26][N:22]1[C:23]2[C:19](=[CH:18][C:17]([CH:15]([C:12]3[N:10]4[N:11]=[C:6]([C:4](=[O:3])[CH3:5])[CH:7]=[CH:8][C:9]4=[N:14][CH:13]=3)[CH3:16])=[CH:25][CH:24]=2)[CH:20]=[N:21]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 669270836-(1-Ethoxy-vinyl)-3-[1-(1-methyl-1H-indazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazine

Product 1

HCID 581904911-(3-(1-(1-Methyl-1H-indazol-5-yl)ethyl)imidazo[1,2-b]pyridazin-6-yl)ethanoneYield 84.8%

Procedure

The title compound (325.0 mg, 75%, 88% pure) was synthesized from 6-(1-ethoxy-vinyl)-3-[1-(1-methyl-1H-indazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazine (415.0 mg, 1.20 mmol) and HCl (1.20 mL, 1.20 mmol) using the same procedure as described in the synthesis of compound 69.4. LCMS (method A): [MH]+=320, tR=5.21 min.

Sources & evidence

ORD record
ord-bcfe61d1c34e4a62aed15a9bc9b1b0d9
Source dataset
uspto-grants-2013_07
Patent number
US08497368B2

Reaction notes

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