Bromomethylcyclopropane → HCID 66891765, compound

HRID 456223Notes

Reaction equation

[OH:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=2[CH2:18][N:19]2[C@@H:23]([CH3:24])[C@@H:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[O:21][C:20]2=[O:31])=[CH:6][C:5]([CH2:32][C:33]([OH:35])=[O:34])=[CH:4][CH:3]=1.Br[CH2:37][CH:38]1[CH2:40][CH2:39]1>>[CH:40]1([CH2:39][O:34][C:33](=[O:35])[CH2:32][C:5]2[CH:6]=[C:7]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:15])([F:16])[F:17])=[CH:10][C:9]=3[CH2:18][N:19]3[C@@H:23]([CH3:24])[C@@H:22]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[O:21][C:20]3=[O:31])[C:2]([O:1][CH2:37][CH:38]3[CH2:40][CH2:39]3)=[CH:3][CH:4]=2)[CH2:38][CH2:37]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 66890151HCID 66890151, compound

Product 1

HCID 66891765HCID 66891765, compound

Procedure

Prepared according to the procedure described in Example 14, Step 3, using the following starting materials: [6-hydroxy-2′-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4′-trifluoromethyl-biphenyl-3-yl]-acetic acid and (bromomethyl)cyclopropane.

Workup

customPrepared

Sources & evidence

ORD record: ord-60624df6ff0d44db90e87e3d5c0b7a76
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08497381B2

Reaction notes

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