HCID 70202042, compound → HCID 67773917, compound

HRID 456253Notes

Reaction equation

HRID 456253 reaction equation
[CH2:1]([N:8]1[CH2:12][C@@H:11]([N:13]([CH2:26]CC(C)C)[S:14]([C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[C@H:10]([NH:31]C(=O)OC(C)(C)C)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O1CCOCC1.Cl>[NH2:31][C@@H:10]1[CH2:9][N:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:12][C@H:11]1[N:13]([CH3:26])[S:14]([C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=1)(=[O:15])=[O:16]

Participants

3

Reactant 1

HCID 70202042HCID 70202042, compound

Product 1

HCID 67773917HCID 67773917, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

A solution of tert-butyl [(3R,4R)-1-benzyl-4-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}pyrrolidin-3-yl]carbamate in 2N HCl dioxane was stirred overnight at room temperature. The solvent was evaporated to a minimal volume, diethyl ether was added, and the formed pellet was filtered off and washed with diethyl ether giving the crude title product which was used in the next step without purification.

Workup

  1. customThe solvent was evaporated to a minimal volume, diethyl ether
  2. additionwas added
  3. filtrationthe formed pellet was filtered off
  4. washwashed with diethyl ether giving the crude title product which
  5. customwas used in the next step without purification

Sources & evidence

ORD record
ord-f6b9aef1cbae4259bae2faf4cc0d9e2d
Source dataset
uspto-grants-2013_07
Patent number
US08497383B2

Reaction notes

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