HCID 68019351, compound → HCID 70197892, compound

HRID 456255Notes

Reaction equation

HRID 456255 reaction equation
[CH2:1]([N:8]1[CH2:12][C@@H:11]([N:13]([CH2:26][CH2:27][CH:28]([CH3:30])[CH3:29])[S:14]([C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[C@H:10]([NH:31][CH2:32][CH2:33][NH:34]C(=O)OC(C)(C)C)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O1CCOCC1.Cl>[NH2:34][CH2:33][CH2:32][NH:31][C@@H:10]1[CH2:9][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:12][C@H:11]1[N:13]([CH2:26][CH2:27][CH:28]([CH3:30])[CH3:29])[S:14]([C:17]1[CH:18]=[CH:19][C:20]([N+:23]([O-:25])=[O:24])=[CH:21][CH:22]=1)(=[O:15])=[O:16]

Participants

3

Reactant 1

HCID 68019351HCID 68019351, compound

Product 1

HCID 70197892HCID 70197892, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

A solution of tert-butyl (2-{[(3R,4R)-1-benzyl-4-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}pyrrolidin-3-yl]amino}ethyl)carbamate in 2N HCl dioxane was stirred overnight at room temperature before the solvent was evaporated to dryness. The resulting tris HCl salt was used directly in the next reaction.

Workup

  1. customwas evaporated to dryness
  2. customThe resulting tris HCl salt was used directly in the next reaction

Sources & evidence

ORD record
ord-3c544afde81045bcbe2fb4527f148a07
Source dataset
uspto-grants-2013_07
Patent number
US08497383B2

Reaction notes

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