HCID 70198456, compound → HCID 67776146, compound

HRID 456261Notes

Reaction equation

HRID 456261 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][C@@H:11]([CH2:13][CH2:14][CH2:15][OH:16])[C@H:10]([NH:17]C(=O)OCC2C=CC=CC=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[NH2:17][C@H:10]1[C@H:11]([CH2:13][CH2:14][CH2:15][OH:16])[CH2:12][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:9]1

Participants

4

Reactant 1

HCID 70198456HCID 70198456, compound

Product 1

HCID 67776146HCID 67776146, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Benzyl (3S*,4R*)-1-(tert-butoxycarbonyl)-4-(3-hydroxypropyl)pyrrolidin-3-ylcarbamate (0.98 g, 2.59 mmol) was hydrogenated over 10% Pd/C (0.05 g) in MeOH for 3 hours at ambient pressure. The catalyst was filtered off and the solvent was evaporated giving the title compound.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-d9d71ce723994eaaacad3c184a3e7052
Source dataset
uspto-grants-2013_07
Patent number
US08497383B2

Reaction notes

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