反应详情

A mixture of 3 g (0.01 mol) of ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate, 2.8 g (0.02 mol) of potassium carbonate and 6 g (0.04 mol) of n-propyl bromide is heated for 5 hours at 80°-90° C. and left to cool, water is added and the precipitate formed is filtered off, washed with water and recrystallized from ethanol to give 2.4 g of a solid melting at 128°-130° C.

1. temperatureis heated for 5 hours at 80°-90° C.
2. waitleft
3. temperatureto cool
4. customthe precipitate formed
5. filtrationis filtered off
6. washwashed with water
7. customrecrystallized from ethanol