4-Methylphenethyl alcohol → HCID 66811767, compound

HRID 456311Notes

Reaction equation

HRID 456311 reaction equation
C([O:5][C:6](=[O:18])[CH2:7][NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)(C)(C)C.[CH3:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27]O)=[CH:22][CH:21]=1>>[CH3:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][O:16][C:13]2[CH:12]=[CH:11][C:10]([C:9]([NH:8][CH2:7][C:6]([OH:5])=[O:18])=[O:17])=[CH:15][CH:14]=2)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 952944-Methylphenethyl alcoholHCID 10682169N-(4-Hydroxybenzoyl)glycine tert-butyl ester

Product 1

HCID 66811767HCID 66811767, compoundYield 90%

Procedure

The same reaction as in Example 1 (1b) was conducted using N-(4-hydroxybenzoyl)glycine tert-butyl ester (275 mg, 1.09 mmol) prepared in Example 1 (1a) and 2-(4-methylphenyl)ethanol (159 μL, 1.14 mmol) to give 306 mg of the title compound (colorless crystalline solid, yield: 90%).

Sources & evidence

ORD record
ord-e2330027bce847d9be392375f549a897
Source dataset
uspto-grants-2013_07
Patent number
US08497397B2

Reaction notes

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