Hydrochloric Acid → methyl (1R,2S)-2-aminocyclohexanecarboxylate

Participants

Reaction Steps

To a solution of (1R,2S)-2-aminocyclohexanecarboxylic acid (0.13 g, 0.91 mmol) in methanol (5 mL) was added 4N HCl in dioxane (1 mL) and the reaction mixture was stirred at reflux overnight. The reaction mixture was concentrated in vacuo to afford an oil which was used directly for the next step.

Provenance & Evidence