Hydrochloric Acid → methyl (1R,2S)-2-aminocyclohexanecarboxylate

HRID 456344Notes

Reaction equation

HRID 456344 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[C:8]([OH:10])=[O:9].Cl.[CH3:12]O>O1CCOCC1>[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[C:8]([O:10][CH3:12])=[O:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2724639(1R,2S)-2-Aminocyclohexane-1-carboxylic acid

Product 1

HCID 24751169methyl (1R,2S)-2-aminocyclohexanecarboxylate

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of (1R,2S)-2-aminocyclohexanecarboxylic acid (0.13 g, 0.91 mmol) in methanol (5 mL) was added 4N HCl in dioxane (1 mL) and the reaction mixture was stirred at reflux overnight. The reaction mixture was concentrated in vacuo to afford an oil which was used directly for the next step.

Workup

  1. temperatureat reflux overnight
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customto afford an oil which

Sources & evidence

ORD record
ord-7b5199e480814c199aae2ee682c9f47c
Source dataset
uspto-grants-2013_07
Patent number
US08497275B2

Reaction notes

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