Bicarbonate Ion → HCID 23535375, compound

HRID 456377Notes

Reaction equation

HRID 456377 reaction equation
[As:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([CH2:12][S:13][CH2:14][CH2:15][C:16]([NH:18][C@H:19]([C:24]([OH:26])=[O:25])[CH2:20][C:21](O)=O)=[O:17])=[O:11])=[CH:5][CH:4]=1)=[O:2].SCCC(N[C@H](C([O-])=O)CC[C:36]([O-:38])=[O:37])=O.[Na+].[Na+].C(=O)(O)[O-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>CS(C)=O>[As:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([CH2:12][S:13][CH2:14][CH2:15][C:16]([NH:18][C@H:19]([C:24]([OH:26])=[O:25])[CH2:20][CH2:21][C:36]([OH:38])=[O:37])=[O:17])=[O:11])=[CH:5][CH:4]=1)=[O:2]

Participants

6

Reactant 4

HCID 769Bicarbonate IonHCID 11776TriphenylphosphineHCID 23535373HCID 23535373, compoundHCID 86593470HCID 86593470, compound

Product 1

HCID 23535375HCID 23535375, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent3×

Procedure

The procedure used was the same as for N-(3-(4-arsenosophenylcarbamoylmethylthio)propanoyl)-L-aspartic acid, using 2.63 mL (184 μmol) of 70.0 mM BRAO in DMSO, the disulfide of disodium N-(3-mercaptopropanoyl)-L-glutamate (0.61 g), 0.5 M bicarbonate buffer, pH 9 (10.52 mL, 5.3 mmol), and 0.69 M triphenylphosphine in DMSO (1.7 mL, 1.2 mmol). In this case, DMSO (2 mL) was added to the precipitated mixture before leaving overnight. The active concentration of trivalent arsenic was found to be 15.4 mM (10.3 mL of solution).

Workup

  1. custombefore leaving overnight
  2. concentrationThe active concentration of trivalent arsenic

Sources & evidence

ORD record
ord-4f38dba369d24a57800074358c31c7c7
Source dataset
uspto-grants-2007_03
Patent number
US07186695B2

Reaction notes

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