Pyridine → HCID 18436619, compound

HRID 456381Notes

Reaction equation

HRID 456381 reaction equation
[CH3:1][CH2:2][CH2:3][CH:4](O)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].C1(C)C=CC([S:24]([Cl:27])(=[O:26])=[O:25])=CC=1.N1C=CC=CC=1>ClCCl>[CH3:1][CH2:2][CH2:3][CH:4]([S:24]([Cl:27])(=[O:26])=[O:25])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

5

Reactant 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 345414-Hexadecanol

Product 1

HCID 18436619HCID 18436619, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-Hexadecanol (12.29 g 0.051 mol) and p-Toluenesulfonyl chloride (12 g 0.063 mol) were dissolved Pyridine (100 ml) and stirred overnight at room temperature. Dichloromethane (400 ml) was added. Dichloromethane solution was then washed well with water, H2SO4 (3%), water, NaHCO3 (3%) and water, dried with anhydrous magnesium sulphate (10 g). After evaporation of the solvent 20 g of crude 4-Hexadecanesulfonyl chloride was obtained.

Workup

  1. washDichloromethane solution was then washed well with water, H2SO4 (3%), water, NaHCO3 (3%) and water
  2. dry with materialdried with anhydrous magnesium sulphate (10 g)
  3. customAfter evaporation of the solvent 20 g of crude 4-Hexadecanesulfonyl chloride
  4. customwas obtained

Sources & evidence

ORD record
ord-da09bdf779e241ce8305ad63b4c295a1
Source dataset
uspto-grants-2007_03
Patent number
US07186703B2

Reaction notes

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