反应详情

150 ml of a solution of borohydride in tertahydrofurane (1.0 mol/l) is slowly added to a solution of 0.12 mole of 4-(tert-Butoxycarbonyl-hydrazono)-piperidine-1-carboxylic acid tert-butyl ester (intermediate product A9) in 100 ml of dry tetrahydrofurane. After complete addition, the mixture is stirred for another 30 min after which a 100 ml of water is added to destroy the excess of borohydride. Subsequently the tetrahydrofurane is evaporated and the resulting aqeous solution extracted with diethyl ether. After drying the solvent over magnesium sulfate, the ether is evaporated. M. p.112–115° C.

1. additionAfter complete addition
2. additionis added
3. customto destroy the excess of borohydride
4. customSubsequently the tetrahydrofurane is evaporated
5. extractionthe resulting aqeous solution extracted with diethyl ether
6. dry with materialAfter drying the solvent over magnesium sulfate
7. customthe ether is evaporated