3-(4-Chlorobenzoyl)propionic acid → 1-(4-Chlorophenyl)-4-((S)-hexahydropyrrolo[1,2-a]pyrazin-2-yl)butane-1,4-dione

HRID 456413Notes

Reaction equation

HRID 456413 reaction equation
CO[C:3]1[CH:4]=[C:5]([C:11](=[O:25])[CH2:12][CH2:13][C:14]([N:16]2[CH2:21][CH2:20][N:19]3[CH2:22][CH2:23][CH2:24][C@H:18]3[CH2:17]2)=[O:15])[CH:6]=[CH:7][C:8]=1OC.[Cl:26]C1C=CC(C(CCC(O)=O)=O)=CC=1>>[Cl:26][C:8]1[CH:7]=[CH:6][C:5]([C:11](=[O:25])[CH2:12][CH2:13][C:14]([N:16]2[CH2:21][CH2:20][N:19]3[CH2:22][CH2:23][CH2:24][C@H:18]3[CH2:17]2)=[O:15])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 776043-(4-Chlorobenzoyl)propionic acidHCID 248863341-(3,4-Dimethoxyphenyl)-4-((S)-hexahydropyrrolo[1,2-a]pyrazin-2-yl)butane-1,4-dione

Product 1

HCID 248863351-(4-Chlorophenyl)-4-((S)-hexahydropyrrolo[1,2-a]pyrazin-2-yl)butane-1,4-dione

Procedure

279 mg of the title compound were prepared as described for 1-(3,4-dimethoxy-phenyl)-4-((S)-hexahydropyrrolo[1,2-a]pyrazin-2-yl)butane-1,4-dione, using 3-(4-chlorobenzoyl) propionic acid instead of 3-(3,4-dimethoxybenzoyl)propionic acid.

Sources & evidence

ORD record
ord-2b9ad58602cb43b8a84401c1488f3c53
Source dataset
uspto-grants-2007_03
Patent number
US07186721B2

Reaction notes

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