3-(Trifluoromethyl)phenethylic alcohol → (R)-Octahydropyrido[1,2-a]pyrazine-2-carboxylic Acid 2-(3-(trifluoromethyl)phenyl)ethyl Ester

HRID 456419Notes

Reaction equation

HRID 456419 reaction equation
CO[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][O:11][C:12]([N:14]2[CH2:19][CH2:18][N:17]3[CH2:20][CH2:21][CH2:22][CH2:23][C@H:16]3[CH2:15]2)=[O:13])=[CH:5][CH:4]=1.[F:24][C:25]([F:36])([F:35])C1C=C(CCO)C=CC=1>>[F:24][C:25]([F:36])([F:35])[C:4]1[CH:5]=[C:6]([CH2:9][CH2:10][O:11][C:12]([N:14]2[CH2:19][CH2:18][N:17]3[CH2:20][CH2:21][CH2:22][CH2:23][C@@H:16]3[CH2:15]2)=[O:13])[CH:7]=[CH:8][CH:3]=1

Participants

3

Reactant 2

HCID 959263-(Trifluoromethyl)phenethylic alcoholHCID 60009829(S)-octahydropyrido[1,2-a]pyrazine-2-carboxylic acid 2-(4-methoxyphenyl)ethyl ester

Product 1

HCID 60009830(R)-Octahydropyrido[1,2-a]pyrazine-2-carboxylic Acid 2-(3-(trifluoromethyl)phenyl)ethyl Ester

Procedure

48 mg of the title compound was prepared as described for (S)-octahydropyrido[1,2-a]pyrazine-2-carboxylic acid 2-(4-methoxyphenyl)ethyl ester, using 2-(3-(trifluoromethyl)-phenyl)ethanol instead of 2-(4-methoxyphenyl)ethanol.

Sources & evidence

ORD record
ord-708a2b4935504876821dbac77c231538
Source dataset
uspto-grants-2007_03
Patent number
US07186721B2

Reaction notes

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