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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 456419Generated: October 27, 2026

3-(Trifluoromethyl)phenethylic alcohol → (R)-Octahydropyrido[1,2-a]pyrazine-2-carboxylic Acid 2-(3-(trifluoromethyl)phenyl)ethyl Ester

https://huagongshe.com/reaction/456419

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)phenethylic alcoholHCID 95926—
Reactant(S)-octahydropyrido[1,2-a]pyrazine-2-carboxylic acid 2-(4-methoxyphenyl)ethyl esterHCID 60009829—
Product(R)-Octahydropyrido[1,2-a]pyrazine-2-carboxylic Acid 2-(3-(trifluoromethyl)phenyl)ethyl EsterHCID 60009830—

Reaction Steps

48 mg of the title compound was prepared as described for (S)-octahydropyrido[1,2-a]pyrazine-2-carboxylic acid 2-(4-methoxyphenyl)ethyl ester, using 2-(3-(trifluoromethyl)-phenyl)ethanol instead of 2-(4-methoxyphenyl)ethanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07186721B2
Source datasetuspto-grants-2007_03
ORD IDord-708a2b4935504876821dbac77c231538
Source noteuspto-grants-2007_03