反应详情

To a solution of 4-(3,3-diphenyl-propionyl)-piperazine-1-carboxylic acid tert-butyl ester (2.15 g, 5.45 mmol) in dry CH2Cl2 (60 ml) was added TFA (20 ml) and resulting mixture stirred at room temperature for 3 hrs. Solvent and excess TFA was then evaporated and the residue was dissolved in CH2Cl2 (150 ml) and washed with sat. NaHCO3 (2×) and dried over MgSO4. Evaporation of solvent gave 1.65 g of pure product.

1. customresulting mixture
2. customSolvent and excess TFA was then evaporated
3. dissolutionthe residue was dissolved in CH2Cl2 (150 ml)
4. washwashed with sat. NaHCO3 (2×)
5. dry with materialdried over MgSO4
6. customEvaporation of solvent