HCID 69420852, compound → HCID 69423162, compound

HRID 456464Notes

Reaction equation

HRID 456464 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH2:21][CH:22]([NH:24]C(OCC2C=CC=CC=2)=O)[CH3:23])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].CO>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH2:21][CH:22]([NH2:24])[CH3:23])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 69420852HCID 69420852, compound

Product 1

HCID 69423162HCID 69423162, compoundYield 103.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4-[2-(2-Benzyloxycarbonylamino-propoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester (5.7 g, 12.15 mmol) and 10% wet palladium on carbon (5.0 g) were dissolved in methanol (200 mL) at r.t. The solution was stirred under hydrogen for about 4 hours. The mixture was filtered through a bed of celite. The solvent was removed under reduced pressure to afford the title compound as a colorless oil (4.2 g, 100%).

Workup

  1. filtrationThe mixture was filtered through a bed of celite
  2. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-49fbb15a46a34a38a8a313947632c0c0
Source dataset
uspto-grants-2007_03
Patent number
US07186715B2

Reaction notes

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