Hydrochloric Acid → HCID 17952533, compound

Participants

Reaction Steps

To a solution of (1-(4-chloro-benzyl)-2-{4-[2-(2-morpholin-4-yl-ethoxy)-phenyl]-piperazine-1-yl}-2-oxo-ethyl)-carbamic acid tert-butyl ester (23.57 g, 41.1 mmol) in MeOH (225 mL) was added 1.0 M HCl in Et2O. The mixture is stirred at r.t. overnight. The solid was filtered, washed with Et2O and dried under vacuum overnight to afford 2-amino-3-(4-chloro-phenyl)-1-{4-[2-(2-morpholin-4-yl-ethoxy)-phenyl]-piperazine-1-yl}-propan-1-one (19.6 g, 36 mmol, 88%).

Provenance & Evidence