Hydrochloric Acid → HCID 17952533, compound

HRID 456486Notes

Reaction equation

HRID 456486 reaction equation
C(OC(=O)[NH:7][CH:8]([CH2:32][C:33]1[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=1)[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[O:23][CH2:24][CH2:25][N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[CH2:13][CH2:12]1)=[O:10])(C)(C)C.Cl>CO.CCOCC>[NH2:7][CH:8]([CH2:32][C:33]1[CH:34]=[CH:35][C:36]([Cl:39])=[CH:37][CH:38]=1)[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[O:23][CH2:24][CH2:25][N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[CH2:13][CH2:12]1)=[O:10]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 69419053HCID 69419053, compound

Product 1

HCID 17952533HCID 17952533, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of (1-(4-chloro-benzyl)-2-{4-[2-(2-morpholin-4-yl-ethoxy)-phenyl]-piperazine-1-yl}-2-oxo-ethyl)-carbamic acid tert-butyl ester (23.57 g, 41.1 mmol) in MeOH (225 mL) was added 1.0 M HCl in Et2O. The mixture is stirred at r.t. overnight. The solid was filtered, washed with Et2O and dried under vacuum overnight to afford 2-amino-3-(4-chloro-phenyl)-1-{4-[2-(2-morpholin-4-yl-ethoxy)-phenyl]-piperazine-1-yl}-propan-1-one (19.6 g, 36 mmol, 88%).

Workup

  1. filtrationThe solid was filtered
  2. washwashed with Et2O
  3. customdried under vacuum overnight

Sources & evidence

ORD record
ord-eb31f426ec4543efa94e12114c1fbede
Source dataset
uspto-grants-2007_03
Patent number
US07186715B2

Reaction notes

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