反应详情

A solution of aldehyde (c) (1.2 g) in tetrahydrofuran (20 ml) was treated at 0° C. under argon with a solution of trimethylsilylmethylmagnesium chloride in ether (1M; 8 ml, 8 mmol). After 2 hours the mixture was partitioned between ether—half saturated aqueous ammonium chloride solution. The organic extract was dried and evaporated affording an oil (1.6 g).

1. customAfter 2 hours the mixture was partitioned between ether—half saturated aqueous ammonium chloride solution
2. extractionThe organic extract
3. customwas dried
4. customevaporated