Hydrazine hydrate (1:1) → HCID 178424712, compound

HRID 456615Notes

Reaction equation

HRID 456615 reaction equation
Cl[C:2]1[C:7]([C:8]([C:10]2[NH:11][C:12]([CH3:16])=[CH:13][C:14]=2[CH3:15])=O)=[CH:6][CH:5]=[CH:4][N:3]=1.O.[NH2:18][NH2:19]>C(O)C>[CH3:15][C:14]1[CH:13]=[C:12]([CH3:16])[NH:11][C:10]=1[C:8]1[C:7]2[C:2](=[N:3][CH:4]=[CH:5][CH:6]=2)[NH:19][N:18]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18436871(2-chloro-pyridin-3-yl)-(3,5-dimethyl-1H-pyrrol-2-yl)-methanone

Product 1

HCID 178424712HCID 178424712, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of (2-chloro-pyridin-3-yl)-(3,5-dimethyl-1H-pyrrol-2-yl)-methanone (240 mg, 1 mmol) and hydrazine hydrate (0.7 mL) in ethanol (2 mL) was heated at 100–110° C. for overnight. The reaction was concentrated and purified on a silica gel column to give 97 mg (46%) of the titled compound as a light yellow solid.

Workup

  1. temperaturewas heated at 100–110° C. for overnight
  2. concentrationThe reaction was concentrated
  3. custompurified on a silica gel column

Sources & evidence

ORD record
ord-e572594a6a4b4cca880d8f4445bbd6d6
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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