Hydrazine hydrate (1:1) → HCID 178420814, compound

HRID 456617Notes

Reaction equation

HRID 456617 reaction equation
Cl[C:2]1[C:7]([C:8]([C:10]2[NH:11][CH:12]=[CH:13][CH:14]=2)=O)=[CH:6][CH:5]=[CH:4][N:3]=1.O.[NH2:16][NH2:17]>C(O)C>[NH:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[C:8]1[C:7]2[C:2](=[N:3][CH:4]=[CH:5][CH:6]=2)[NH:17][N:16]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13160528(2-Chloropyridin-3-yl)(1H-pyrrol-2-yl)methanone

Product 1

HCID 178420814HCID 178420814, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of (2-chloro-pyridin-3-yl)-(1H-pyrrol-2-yl)-methanone (1 g, 4.8 mmol) and hydrazine hydrate (0.5 mL) in ethanol (15 mL) was heated to reflux for overnight. The reaction was concentrated and the residue was triturated with dichloromethane (to remove any unreacted starting material. The solid was filtered, washed wit water and dried to give 720 mg (81%) of the titled compound as a light yellow solid.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for overnight
  3. concentrationThe reaction was concentrated
  4. customthe residue was triturated with dichloromethane (
  5. customto remove
  6. filtrationThe solid was filtered
  7. washwashed wit water
  8. customdried

Sources & evidence

ORD record
ord-f9cb4e804a964e21ab90878eeb1e1b60
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

Loading…