Hydrazine hydrate (1:1) → HCID 178420100, compound

HRID 456620Notes

Reaction equation

HRID 456620 reaction equation
Cl[C:2]1[C:7]([C:8]([C:10]2[NH:11][CH:12]=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=O)=[CH:6][CH:5]=[CH:4][N:3]=1.O.[NH2:22][NH2:23]>C(O)C>[C:15]1([C:14]2[CH:13]=[CH:12][NH:11][C:10]=2[C:8]2[C:7]3[C:2](=[N:3][CH:4]=[CH:5][CH:6]=3)[NH:23][N:22]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18436872HCID 18436872, compound

Product 1

HCID 178420100HCID 178420100, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of (2-chloro-pyridin-3-yl)-(3-phenyl-1H-pyrrol-2-yl)-methanone (150 mg, 0.53 mmol) from above and hydrazine hydrate (0.5 mL) in ethanol (6 mL) was heated at 90° C. for 24 hours. The reaction was concentrated, the residue was triturated with DCM, filtered to give 77 mg (56%) of the titled compound.

Workup

  1. concentrationThe reaction was concentrated
  2. customthe residue was triturated with DCM
  3. filtrationfiltered

Sources & evidence

ORD record
ord-8a534f5299e1470b8e8ded30c01d8e77
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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