Hydrazine hydrate (1:1) → HCID 178478095, compound

HRID 456622Notes

Reaction equation

HRID 456622 reaction equation
Cl[C:2]1[C:7]([C:8]([C:10]2[NH:11][CH:12]=[C:13]([C:15]3[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:22])[CH:14]=2)=O)=[CH:6][CH:5]=[CH:4][N:3]=1.O.[NH2:24][NH2:25]>C(O)C>[Cl:22][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]([Cl:21])[C:15]=1[C:13]1[CH:14]=[C:10]([C:8]2[C:7]3[C:2](=[N:3][CH:4]=[CH:5][CH:6]=3)[NH:25][N:24]=2)[NH:11][CH:12]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18436873HCID 18436873, compound

Product 1

HCID 178478095HCID 178478095, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of (2-chloro-pyridin-3-yl)-[4-(2,6-dichloro-phenyl)-1H-pyrrol-2-yl]-methanone (150 mg) from above and hydrazine hydrate (0.5 mL) in ethanol (7 mL) was heated at 90–100° C. for overnight. The reaction was concentrated, the residue was washed with water, dried and triturated with ethyl acetate-hexane mixture to give 71 mg of the titled compound.

Workup

  1. temperaturewas heated at 90–100° C. for overnight
  2. concentrationThe reaction was concentrated
  3. washthe residue was washed with water
  4. customdried
  5. customtriturated with ethyl acetate-hexane mixture

Sources & evidence

ORD record
ord-dd72abcb459b44dfb437c7009ab58d0f
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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