反应详情

温度

80 °C

A mixture of 5-(2-chloro-pyridine-3-carbonyl)-1H-pyrrole-3-carboxylic acid ethyl ester (1.2 g, 4.32 mmol) and hydrazine hydrate (6.27 mL) in ethanol (50 mL) was heated at 80° C. for 24 hours. The reaction was concentrated and the residue was neutralized to pH 7 with 1N HCl, extracted with ethyl acetate. The combined ethyl acetate was dried, concentrated and purified on a silica gel column to give the titled compound as a white solid.

1. concentrationThe reaction was concentrated
2. extractionextracted with ethyl acetate
3. dry with materialThe combined ethyl acetate was dried
4. concentrationconcentrated
5. custompurified on a silica gel column