反应详情

温度

40 °C

A mixture of 5-(1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-pyrrole-3-carboxylic acid ethyl ester (200 mg, 0.78 mmol) (from Example 11) and 10% NaOH (10 mL) was stirred at room temperature for one hour, at 40° C. for 2 hours and at room temperature for overnight. The reaction was adjusted to pH 6–7 with concentrated HCl. The precipitate was collected by vacuum filtration, washed with water and dried to give 140 mg (79%) of the titled compound.

1. filtrationThe precipitate was collected by vacuum filtration
2. washwashed with water
3. customdried