Hydrazine hydrate (1:1) → HCID 178527562, compound

HRID 456642Notes

Reaction equation

HRID 456642 reaction equation
[CH2:1]([NH:8][S:9]([C:12]1[CH:16]=[C:15]([C:17]([C:19]2[C:20](Cl)=[N:21][CH:22]=[CH:23][CH:24]=2)=O)[NH:14][CH:13]=1)(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:27][NH2:28]>C(O)C>[CH2:1]([NH:8][S:9]([C:12]1[CH:16]=[C:15]([C:17]2[C:19]3[C:20](=[N:21][CH:22]=[CH:23][CH:24]=3)[NH:28][N:27]=2)[NH:14][CH:13]=1)(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 865922435-(2-chloro-pyridine-3-carbonyl)1H-pyrrole-3-sulfonic acid benzylamide

Product 1

HCID 178527562HCID 178527562, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 5-(2-chloro-pyridine-3-carbonyl)-1H-pyrrole-3-sulfonic acid benzylamide (100 mg), hydrazine hydrate (excess) in ethanol (10 mL) was heated at 80° C. for 48 hours. The reaction was concentrated, mixed with water, the precipitate was filtered off, the filtrate was washed with dilute HCl, water, dried and concentrated to give the titled compound as a light yellow solid.

Workup

  1. concentrationThe reaction was concentrated
  2. additionmixed with water
  3. filtrationthe precipitate was filtered off
  4. washthe filtrate was washed with dilute HCl, water
  5. customdried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-2a1b0aeb7f674e26a6736595803bf2a1
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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