HCID 136358045, compound → HCID 136358049, compound

HRID 456648Notes

Reaction equation

HRID 456648 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([O:13][C:14](=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16])[N:8]=[C:7]2[C:20]1[NH:21][CH:22]=[CH:23][CH:24]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([O:13][C:14](=[O:19])[C:15]([CH3:16])([CH3:17])[CH3:18])[N:8]=[C:7]2[C:20]1[NH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 1

HCID 136358045HCID 136358045, compound

Product 1

HCID 136358049HCID 136358049, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2,2-Dimethyl-propionic acid 5-nitro-3-(1H-pyrrol-2-yl)-indazol-1-yl ester (370 mg, 1.13 mmol) (from Example 28) was hydrogenated using 10% Pd/C in ethanol (35 mL) at room temperature for 2 hours. The reaction was filtered and the filtrate was concentrated to give 2,2-dimethyl-propionic acid 5-amino-3-(1H-pyrrol-2-yl)-indazol-1-yl ester.

Workup

  1. customat room temperature
  2. customfor 2 hours
  3. filtrationThe reaction was filtered
  4. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-bcc46733c0dc4177af5baf467b9e2724
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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