p-Anisoyl chloride → HCID 135499984, compound

HRID 456651Notes

Reaction equation

HRID 456651 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][CH:24]=1)[C:5]([NH:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][N:12]=[C:11]2[C:17]1[NH:18][CH:19]=[CH:20][CH:21]=1)=[O:6].[CH3:25][O:26]C1C=CC(C(Cl)=O)=CC=1.C(N(CC)CC)C>C(Cl)Cl>[CH3:25][O:26][C:24]1[CH:23]=[CH:22][C:4]([C:5]([NH:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][N:12]=[C:11]3[C:17]2[NH:18][CH:19]=[CH:20][CH:21]=2)=[O:6])=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 7477p-Anisoyl chlorideHCID 8471TriethylamineHCID 135517309HCID 135517309, compound

Product 1

HCID 135499984HCID 135499984, compoundYield 102.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2,2-Dimethyl-propionic acid 5-amino-3-(1H-pyrrol-2-yl)-indazol-1-yl ester (0.38 mmol) (from Example 25) was coupled with 4-methoxy-benzoyl chloride (0.4 mmol) and triethylamine in DCM at 0° C. to give 130 mg of the titled compound as a white solid.

Sources & evidence

ORD record
ord-08da0665dd5f4a5a824555c94d416ace
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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