Hydrazine hydrate (1:1) → HCID 178485302, compound

HRID 456660Notes

Reaction equation

HRID 456660 reaction equation
[CH3:1][NH:2][C:3]([C:5]1[NH:6][C:7]([C:10]([C:12]2[C:13](Cl)=[N:14][CH:15]=[CH:16][CH:17]=2)=O)=[CH:8][CH:9]=1)=[O:4].O.[NH2:20][NH2:21]>C(O)C>[CH3:1][NH:2][C:3]([C:5]1[NH:6][C:7]([C:10]2[C:12]3[C:13](=[N:14][CH:15]=[CH:16][CH:17]=3)[NH:21][N:20]=2)=[CH:8][CH:9]=1)=[O:4]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 859347595-(2-chloro-pyridine-3-carbonyl)-1H-pyrrole-2-carboxylic acid methylamide

Product 1

HCID 178485302HCID 178485302, compoundYield 27%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 5-(2-chloro-pyridine-3-carbonyl)-1H-pyrrole-2-carboxylic acid methylamide (320 mg, 1.2 mmol) and hydrazine hydrate (2 mL) in ethanol (20 mL). The mixture was heated to at 80° C. for 48 hours. The precipitate was collected by vacuum filtration, washed with ethanol and water, dried to give 80 mg (27%) of the titled compound.

Workup

  1. filtrationThe precipitate was collected by vacuum filtration
  2. washwashed with ethanol and water
  3. customdried

Sources & evidence

ORD record
ord-851fb82f2c894653b4361c8b20316986
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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