反应详情

温度

80 °C

A mixture of 5-(2-chloro-pyridine-3-carbonyl)-1H-pyrrole-2-carboxylic acid ((S)-1-phenyl-ethyl)-amide (450 mg, 1.3 mmol) and hydrazine hydrate (2 mL) in ethanol (20 mL) was heated at 80° C. for 24 hours. The reaction was concentrated, the residue was triturated with water. The precipitate was collected by vacuum filtration, washed with water and DCM to give 80 mg (19%) of the titled compound.

1. concentrationThe reaction was concentrated
2. customthe residue was triturated with water
3. filtrationThe precipitate was collected by vacuum filtration
4. washwashed with water and DCM